Glass bottle labelled ‘Quinine Disulph.’ Bottle empty. Quinine occurs naturally in the bark of the cinchona tree. The medicinal properties of the cinchona tree were originally discovered by the Quechua, who are indigenous to Peru and Bolivia; later, the Jesuits were the first to bring the cinchona to Europe. Savory, 'A companion to the Medicine Chest', 1836, p.73-4: “Quinine, Sulphate of. Is the name given to the newly discovered preparation derived from Peruvian bark, which contains all its active principles in a concentrated state, divested of extraneous matter; and the dose being consequentially small, it is likely to produce nausea or any derangement of stomach than bark in substance. It is often very desirable to administer this medicine in a small volume, and in an agreeable form. Patients often die of malignant fevers because they cannot swallow the necessary quantity of the bark in powder. (...) Chemistry, therefore, has done a great service to medicine by shewing how this separation may be accomplished beforehand. Sulphate of quinine is now generally prescribed in all cases where bark in substance has been usually given. (…)" (Goes on to describe use of quinine in tooth- and jawache).